HEALING MONOGRAPH
BPC-157 Research Monograph
Body Protection Compound 157 — pentadecapeptide tissue-repair research
BPC-157 (Body Protection Compound 157) is a synthetic 15-amino-acid peptide derived from a stable protein in human gastric juice. It is among the most extensively published peptides in modern preclinical tissue-repair research literature, with foundational work running from the late 1990s through the present day.
Discovery and naming
BPC-157 was characterised by the research group of Predrag Sikiric at the University of Zagreb in the 1990s. The parent compound — "Body Protection Compound" — refers to a stable cytoprotective gastric protein from which the 15-amino-acid fragment was derived. The numerical suffix denotes the specific 15-mer sub-sequence selected as the active research compound.
Sequence and structure
The published BPC-157 sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Molecular weight is 1419.5 g/mol. The peptide is unusually stable in gastric juice — a defining feature of the parent BPC family — and is supplied for research as a sterile lyophilised powder for reconstitution.
Primary research literature
BPC-157's published research clusters around tendon and ligament repair models, gastric mucosal protection studies, vascular research, and central- and peripheral-nervous-system injury models. The Sikiric laboratory and collaborating groups have published a substantial body of preclinical work characterising the compound across multiple model systems.
Storage, reconstitution, and handling
Lyophilised BPC-157 is stable for months at −20°C in its sealed vial when protected from light and moisture. After reconstitution with bacteriostatic water or sterile saline, working solutions should be stored at 2–8°C and used within 7 days. Avoid repeated freeze-thaw cycles of reconstituted material.
Pentadeca Arginate as a stability-enhanced alternative
An arginate-salt analogue — Pentadeca Arginate (PDA) — has emerged in research-supply catalogues since 2024 as a more storage-stable variant of the same 15-amino-acid backbone. PDA replaces BPC-157's four free carboxylate groups with arginine counter-ions, increasing molecular weight to roughly 1635 g/mol and extending reconstituted shelf life. Selection between BPC-157 and PDA depends on whether literature continuity (BPC-157) or extended reconstituted stability (PDA) is the priority for the experimental design.
Quality and verification
VESPER BPC-157 is supplied at ≥99.5% HPLC purity, with sequence identity confirmed by mass spectrometry on every batch. Batch-specific certificates of analysis are provided alongside each vial.
Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular weight
1419.5 g/mol
CAS
137525-51-0
Purity
≥99.5%
Storage
−20°C, protected from light
Vial format
5mg / vial
Frequently asked
What is the BPC-157 amino acid sequence?
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. A 15-amino-acid peptide with molecular weight of approximately 1419.5 g/mol.
How should BPC-157 be stored?
Lyophilised BPC-157 is stable for months at −20°C in its sealed vial. After reconstitution, store at 2–8°C and use within 7 days.
Is Pentadeca Arginate the same as BPC-157?
PDA shares the 15-amino-acid sequence but is supplied as an arginate salt rather than the free peptide. The arginate form provides extended reconstituted stability.
⚠ For research use only. Not for human consumption.